Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 105, Issue 5, Pages 1460-1465Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0711625105
Keywords
c-1027; neocarzinostatin; phosphopantetheinyl transferase
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Funding
- NCI NIH HHS [CA113297, U19 CA113297, CA1059845, F32 CA105984] Funding Source: Medline
- NIGMS NIH HHS [F32 GM073323, GM073323, R01 GM067725, GM067725] Funding Source: Medline
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The enediynes, unified by their unique molecular architecture and mode of action, represent some of the most potent anticancer drugs ever discovered. The biosynthesis of the enediyne core has been predicted to be initiated by a polyketide synthase (PKS) that is distinct from all known PKSs. Characterization of the enediyne PKS involved in C-1027 (SgcE) and neocarzinostatin (NcsE) biosynthesis has now revealed that (i) the PKSs contain a central acyl carrier protein domain and C-terminal phosphopantetheinyl transferase domain; (if) the PKSs are functional in heterologous hosts, and coexpression with an enediyne thioesterase gene produces the first isolable compound, 1,3,5,7,9,11,13-pentadecaheptaene, in enediyne core biosynthesis; and (fit) the findings for SgcE and NcsE are likely shared among all nine-membered enediynes, thereby supporting a common mechanism to initiate enediyne biosynthesis.
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