Journal
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
Volume 90, Issue 3, Pages 83-96Publisher
JAPAN ACAD
DOI: 10.2183/pjab.90.83
Keywords
iPS cell; reprogramming; pluripotent
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The reversion of cell fate from differentiated states back into totipotent or pluripotent states has been an interest of many scientists for a long time. With the help of knowledge accumulated by those scientists, we succeeded in converting somatic cells to a pluripotent cell lineage by the forced expression of defined factors. These established induced pluripotent stem (iPS) cells have similar features to embryonic stem (ES) cells, including pluripotency and immortality. The iPS cell technology provides unprecedented opportunities for regenerative medicine and drug discovery.
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