Journal
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
Volume 224, Issue H12, Pages 1441-1453Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1243/09544119JEIM775
Keywords
focal adhesions; biomaterials; differentiation; cell signalling
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Funding
- AO Research Fund, Switzerland [04-D81]
- National Institute Of Health, Nanomedicine Roadmap Initiative [PN2EY016586]
- Biotechnology and Biological Sciences Research Council
- NATIONAL EYE INSTITUTE [PN2EY016586] Funding Source: NIH RePORTER
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As materials technology and the field of tissue engineering advance, the role of cellular adhesive mechanisms, in particular, interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material surface or chemical stimuli in order to help to develop next-generation biomaterials. The focus of this review is on recent studies and developments concerning focal adhesion formation in osteoneogenesis, with an emphasis on the influence of synthetic constructs on integrin-mediated cellular adhesion and function.
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