Journal
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
Volume 8, Issue 9, Pages 536-544Publisher
SPRINGER
DOI: 10.1007/s12265-015-9659-8
Keywords
Myocarditis; Panax notoginseng saponins; Hydrogen sulfide; Cystathionine-gamma-lyase
Funding
- Zhejiang Provincial Natural Science Foundation of China [LY12H02003]
- Zhejiang Provincial Medical and Health Science and Technology plan [2010KYA138, 2012ZDA035]
- Zhejiang Province TCM Science and Technology plan [2010ZA089]
- Scientific Research Foundation of Wenzhou [Y20140051]
- Project of Science and Technology Department of Zhejiang Province [2015C33163]
- National Institutes of Health [HL109656, NR013876]
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This study is to determine the therapeutic effects of Panax notoginseng saponins (PNSs) on coxsackievirus B3 (CVB3)-induced myocarditis, and whether cystathionine-gamma-lyase (CSE)/hydrogen sulfide (H2S) pathway is involved. Mouse model of myocarditis was induced by CVB3 infection, and the mice were subjected to vehicle (saline) or drug treatments (sodium bisulfide (NaHS), propargylglycine (PAG), or PNSs). The results showed that there were inflammatory cell infiltrations, interstitial edemas, and elevated inflammatory cytokines, in CVB3-induced myocarditis. PAG administration increased, whereas NaHS treatment decreased the severity of the myocarditis. PNS treatment dramatically alleviated these myocardial injuries and decreased the viral messenger RNA (mRNA) expression by the enhanced expression of CSE/H2S pathway. Moreover, the therapeutic effects of PNSs on myocarditis were stronger than those of NaHS. Finally, the effect of PNSs on CSE/H2S pathway and cardiac cell protection were verified in cultured cardiac cells. PNSs may be a promising medication for viral myocarditis therapy.
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