Journal
CELL DEATH & DISEASE
Volume 6, Issue -, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/cddis.2015.162
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Funding
- National Natural Science Foundation of China [31170838, 81472435, 81071772, 81222031]
- National Key Basic Research Program of China (973 program) [2012CB526603]
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T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to the failure of cancer elimination. Restoring exhausted T cells represents an inspiring strategy for cancer treatment, which has yielded promising results and become a significant breakthrough in the cancer immunotherapy. In this review, we overview the updated understanding on the exhausted T cells in cancer and their potential regulatory mechanisms and discuss current therapeutic interventions targeting exhausted T cells in clinical trials.
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