Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 7, Issue 8, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a019141
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Funding
- Federation of European Biochemical Societies (FEBS) long-term Fellowship
- Louis Jeantet Foundation
- Swiss National Science Foundation
- Canton of Basel
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Cell growth is a highly regulated, plastic process. Its control involves balancing positive regulation of anabolic processes with negative regulation of catabolic processes. Although target of rapamycin (TOR) is a major promoter of growth in response to nutrients and growth factors, AMP-activated protein kinase (AMPK) suppresses anabolic processes in response to energy stress. Both TOR and AMPK are conserved throughout eukaryotic evolution. Here, we review the fundamentally important roles of these two kinases in the regulation of cell growth with particular emphasis on their mutually antagonistic signaling.
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