Journal
PRION
Volume 3, Issue 1, Pages 44-48Publisher
LANDES BIOSCIENCE
DOI: 10.4161/pri.3.1.8442
Keywords
prion disease; immunodetection; PrPSc
Categories
Funding
- National Center for Research Resources [P20 RR0115635-6, C06 RR17417-01]
- National Institute for Neurological Disorders and Stroke [R01 NS052609]
- National Prion Research Program [NP020041]
- NATIONAL CENTER FOR RESEARCH RESOURCES [C06RR017417] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS052609] Funding Source: NIH RePORTER
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Prion diseases are emerging infectious disorders that affect several mammalian species including humans. The transmissible agent is comprised of PrPSc, a misfolded isoform of the normal host-encoded prion protein PrPC. Immunodetection of PrPSc is often utilized for prion disease diagnosis and tracking spread of the infectious agent through the host. We have developed a rapid, high-throughput 96-well immunoassay, which is specific for the detection of PrPSc. This assay has PrPSc detection limits similar to western blot and is advantageous because of its comparatively shorter running time, smaller start-up and operation costs and large sample capacity.
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