Journal
PRIMARY CARE
Volume 41, Issue 4, Pages 875-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pop.2014.08.008
Keywords
Obesity; Kidney; Hypertension; Insulin resistance; Inflammation
Categories
Ask authors/readers for more resources
The prevalence of chronic kidney disease (CKD) is increasing, and the epidemic of obesity is one of the causes. Obesity exacerbates hypertension as a risk factor for CKD, causing vasoconstriction and salt and water retention. Obesity also worsens glucose intolerance and insulin resistance as risk factors for CKD. Obesity targets the kidney by triggering novel pathways of intrarenal inflammation, recruiting professional immunologic cells through metaflammation. Obesity-related glomerulopathy has emerged as a distinct pathologic variant of focal segmental glomerulosclerosis. No definitive treatments have come about for obesity-related glomerulopathy, but among the most promising prospects is aggressive weight loss, including bariatric surgery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available