Journal
PREVENTIVE MEDICINE
Volume 57, Issue 5, Pages 567-572Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ypmed.2013.07.022
Keywords
Exercise; Myocardial infarction; Physical activity; Prevention; Public health
Funding
- AstraZeneca
- Fondo de Investigacion Sanitaria-Instituto Carlos III/European Development Research Funds (Red de Investigacion Cardiovascular) [RD12/0042/0013, RD12/0042/0040, RD12/0042/0061, FIS PI081327, FIS C03/09, FIS C03/045]
- CIBER Epidemiologia y Salud Publica (CIBERESP)
- CIBER Obesidad y Nutricion (CIBEROBENU)
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Objective. The aims of this study were to analyze the dose-response association between leisure time physical activity (PA) practice and myocardial infarction (MI), considering not only the total amount but also the amount of PA at different levels of intensity, and to determine whether these associations were modified by age. Method. In a population-based age- and sex-matched case-control study, all first acute MI patients aged 25 to 74 years were prospectively registered in four Spanish hospitals between 2002 and 2004. Controls were randomly selected from population-based samples recruited during the same period of time. The Minnesota PA questionnaire was administered to assess total energy expenditure in PA and in light-, moderate-, and high-intensity PA Results. Finally, 1339 cases and 1339 controls were included. The association between PA and MI likelihood was non-linear, with significantly lower MI odds at low practice levels (>= 500 MET.min/week), lowest odds around 1500 MET.min/week, and a plateau thereafter. Light- (in subjects older than 64 years), moderate-, and high-intensity PA produced similar benefits. Conclusion. Most of the population could reduce their likelihood of MI by engaging in PA at a moderate level of intensity or, in individuals older than 64 years, at a light level of intensity. (C) 2013 Elsevier Inc. All rights reserved.
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