Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 19, Issue -, Pages 744-752Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2015.10.006
Keywords
Probiotic; Weight loss; Fat mass; Lp-PLA(2); CT; DEXA
Categories
Funding
- Bio & Medical Technology Development Program of the National Research Foundation of Korea (NRF) [NRF-2012M3A9C4048762]
- Ministry of Science, ICT & Future Planning, Korea
- Food Functionality Evaluation program under the Ministry of Food, Agriculture, Forestry and Fisheries, Korea
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The effect of consumption of two probiotic strains, Lactobacillus curuatus HY7601 and Lactobacillus plantarum KY1032, on weight loss, body adiposity and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activities in overweight subjects was examined. After 12-week probiotic treatment, the probiotic group presented reductions in body weight (-0.65 +/- 0.23 kg), body fat percentage (-0.57 +/- 0.19%) and body fat mass (-616 +/- 161 g) measured using DEXA, and L1 subcutaneous fat area (-2.68 +/- 1.31 cm(2)) measured using CT, compared to baseline. The probiotic group exhibited greater reductions in oxidized low density lipoprotein (ox-LDL) (P < 0.001) and Lp-PLA(2) (P < 0.001) and a greater increase in low density lipoprotein (LDL) particle size (P = 0.001) than the placebo. The change (Delta, difference from baseline) in total fat mass correlated with Delta Lp-PLA(2) (r = 0.480, P < 0.001), which correlated with Delta, ox-LDL (r = 0.537, P < 0.001). Probiotic-induced weight loss was associated with reductions in fat mass, which correlated with the changes in Lp-PLA(2) activities. (C) 2015 Elsevier Ltd. All rights reserved.
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