Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 13, Issue -, Pages 204-213Publisher
ELSEVIER
DOI: 10.1016/j.jff.2014.12.034
Keywords
Weight gain; beta-defensins; Bifidobacteria; Gut microbiota; Lachnospiraceae; Mucin
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Funding
- Fonterra Co-operative Group Ltd, Palmerston North, New Zealand [28481]
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The effects of probiotics (Bifidobacterium animal is subsp. lactis HN019 and Lactobacillus rhamnosus HN001) and prebiotics (fructo-oligosaccharide (FOS), galacto-oligosaccharide (GOS), and inulin) individually and in synbiotic combinations (B. laths HN019+FOS, B. laths HN019+GOS, B. laths HN019+inulin, L. rhamnosus HN001+FOS, L. rhamnosus HN001+GOS, and L. rhamnosus HN001+inulin) on large bowel health were investigated in rats fed the respective diets for 21 days. All experimental treatments led to significantly lower body weight gains and decreased caecal acetic acid concentrations compared to the control diet (no pro-, pre-, and synbiotics). Caecal Bifidobacterium spp. or Lachnospiraceae were increased in L. rhamnosus HN001, FOS or inulin treatments. Rats fed L. rhamnosus HN001 had enhanced colonic beta-defensin 1 and mucin (MUC)-4 gene expression. All synbiotic combinations increased the MUC4 gene expression. The pro-, pre-, and synbiotics had beneficial effects on the biomarkers of large bowel health in rats. A selective inclusion of pro-, pre-, and synbiotics in the diet will be required to achieve desired health benefits. (C) 2014 Elsevier Ltd. All rights reserved.
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