Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 19, Issue -, Pages 363-375Publisher
ELSEVIER
DOI: 10.1016/j.jff.2015.09.033
Keywords
Functional foods; High-cholesterol diet; Metabolomics; Nutraceuticals; Onion metabolism; Plasma fingerprinting
Categories
Funding
- Spanish Ministry of Science and Innovation (subprogram ALI) [AGL2010-15910]
- Spanish Ministry of Economy and Competitiveness [AGL2013-46326-R, CTQ2014-55279-R]
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The preventive and modulating effects of onion in metabolites affected by a high-cholesterol diet and related to molecular pathway dysfunction were examined. Plasma obtained from 24 male Wistar rats after seven weeks of experimental feeding was analysed through a non-targeted multiplatform metabolomics approach based on LC-MS, CE-MS and GC-MS methods. A cross-comparison of the three metabolic profiles [I) control (C) group, II) high-cholesterol (HC) group and III) high-cholesterol enriched with onion (HCO) group] pointed out two sulphur metabolites, S-methyl-L-cysteine and S-methylcysteine sulphoxide, as markers of onion intake and evidenced the possibilities to regulate key metabolites. Thus, the methylation cycle, arginine and tryptophan pathways, the modulation of 3-methylhistidine, as well as the routes involved in the glycerophospholipids transformation have been highlighted. This study suggests that onion's biologically active compounds take a prominent role in ameliorating hypercholesterolaemia and related complications through the regulation of altered metabolic pathways. (C) 2015 Elsevier Ltd. All rights reserved.
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