Journal
ONCOTARGETS AND THERAPY
Volume 8, Issue -, Pages 2903-2914Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S92470
Keywords
ALL; microRNA; lymphopoiesis; molecular diagnosis; lymphoid malignant; molecular therapy
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Funding
- National Natural Science Foundation of the People's Republic of China [81170492, 81370673]
- National High Technology Research and Development Program 863 of the People's Republic of China [2012AA022703]
- National Key Basic Research Program 973 of the People's Republic of China [2010CB732404]
- Key Medical Projects of Jiangsu Province [BL2014078]
- Key Discipline of Jiangsu Province
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MicroRNAs (miRNAs), a new class of noncoding RNAs, which can hybridize to target messenger RNAs and regulate their expression posttranscriptionally, express differentially in distinct stages of lymphopoiesis and influence the direction of lymphoid precursor maturation. Hence, there is aberrant expression of miRNAs involved in malignant lymphopoiesis, and these aberrations can be used as signatures of acute lymphoblastic leukemia (ALL) with different subtypes. In addition, changes in the expression of several miRNAs may have functional relevance with leukemogenesis or drug resistance. As a result, the reversal of the expression of these miRNAs may alleviate the disease to some extent and improve clinical outcomes. However, among the studies of miRNAs, there are still some problems that need to be solved to understand the function of miRNAs in ALL more thoroughly.
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