Journal
MEDCHEMCOMM
Volume 6, Issue 6, Pages 1024-1029Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5md00037h
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A series of 2-(pyridinyl) pyrimidines were identified as potent GPR40 antagonists. Despite significant challenges related to improving the combination of potency and lipophilicity within the series, the compounds were optimised to identify a suitable in vivo probe compound, which was confirmed to exhibit pharmacology consistent with GPR40 antagonism.
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