Journal
POLYMERS FOR ADVANCED TECHNOLOGIES
Volume 24, Issue 9, Pages 824-833Publisher
WILEY-BLACKWELL
DOI: 10.1002/pat.3150
Keywords
PVA hydrogels; STMP; ToF SIMS; cartilage; rheology
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Funding
- Italian Interuniversity Consortium CSGI
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PVA based hydrogel was synthesised using, as crosslinking agent, trisodium trimetaphosphate (STMP) and its morphology was modified inducing a microporous structure to obtain potential substitutes for cartilage tissue. The hydrogel was characterised by Infrared Spectroscopy combined with Time of flight mass spectrometry (ToF-SIMS) that confirmed the successful occurrence of crosslinking reaction, the hyphotised crosslinking arm and its homogeneous distribution. The mechanical spectra of the fully hydrated samples confirmed covalently crosslinked systems with a rheological behaviour similar to that of tibial cartilage. Further analysis in terms of water content measurements, thermal stability and cytotoxicity confirmed the applicability of such a hydrogel as cartilage substitute. Copyright (c) 2013 John Wiley & Sons, Ltd.
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