Journal
MEDCHEMCOMM
Volume 6, Issue 8, Pages 1420-1426Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5md00238a
Keywords
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Funding
- Cancer Research Campaign
- Cancer Research UK
- Professorial Life Fellowship
- Medical Research Council
- Royal Pharmaceutical Society
- Wellcome Trust
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Academic drug discovery is playing an increasingly important role in the identification of new therapies for a wide range of diseases. There is no one model that guarantees success. We describe here a drug discovery story where chance, the ability to capitalise on chance, and the assembling of a range of expertise, have all played important roles in the discovery and subsequent development of an antibiotic chemotype based on the bis-benzimidazole scaffold, with potency against a number of current therapeutically challenging diseases. One compound in this class, SMT19969, has recently entered Phase 2 human clinical trials for the treatment of Clostridium difficile infections.
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