Journal
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
Volume 52, Issue 4, Pages 368-380Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/03602559.2012.751999
Keywords
Chitosan; Complexation; Mucin; Mucoadhesion; PLGA; Polymer grafting; Surface modification
Categories
Ask authors/readers for more resources
The objective of present study was to modify the surface of Poly(D,L-lactide-co-glycolide acid) (PLGA) nanoparticles (NPs) with chitosan to enhance the mucoadhesive potential of carrier system. Grafting of chitosan on PLGA surface was carried out via amide bond formation mediated by carbodiimide and confirmed by FTIR spectroscopy. Self-assembled PLGA NPs containing chlorpromazine hydrochloride were fabricated by 23 factorial design. The improved mucoadhesive potential was confirmed by several tests including in vitro mucoadhesion study. Ex vivo permeation was satisfactory. Histopathological study on sheep nasal mucosa revealed safe mucoadhesion. They were also found to be robust on accelerated stability study.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available