Journal
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
Volume 50, Issue 13, Pages 1367-1374Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/03602559.2011.584240
Keywords
Bio-ceramic; Biocompatibility; Composite; Polyamide 6; Scaffold
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Funding
- China 973 Fund [2007CB936102]
- China 863 Fund [2007AA03Z328766]
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A porous scaffold of bio-ceramic/polyamide 6 (PA 6) has been fabricated through a thermally induced phase separation technique. The scaffold was characterized by XPS, SEM and mechanical test. The results revealed that bio-ceramic/PA 6 scaffold had an interconnected porous structure with a porosity of about 78%. Moreover, bio-ceramic/PA 6 scaffolds were cultured with BMSCs to investigate their in vitro cytocompatibility, and they were implanted in subcutaneous sites of mice for 4 and 8 weeks to evaluate their in vivo histocompatibility. The result showed the composite scaffolds provided a favourable environment for initial cell adhesion, maintained cell viability and cell proliferation, and had good tissue compatibility.
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