Bioactive Ceramic/Polyamide 6 Scaffold for Bone Regeneration: In vitro and in vivo Evaluation

A porous scaffold of bio-ceramic/polyamide 6 (PA 6) has been fabricated through a thermally induced phase separation technique. The scaffold was characterized by XPS, SEM and mechanical test. The results revealed that bio-ceramic/PA 6 scaffold had an interconnected porous structure with a porosity of about 78%. Moreover, bio-ceramic/PA 6 scaffolds were cultured with BMSCs to investigate their in vitro cytocompatibility, and they were implanted in subcutaneous sites of mice for 4 and 8 weeks to evaluate their in vivo histocompatibility. The result showed the composite scaffolds provided a favourable environment for initial cell adhesion, maintained cell viability and cell proliferation, and had good tissue compatibility.