Journal
BIOANALYSIS
Volume 7, Issue 9, Pages 1119-1136Publisher
FUTURE SCI LTD
DOI: 10.4155/bio.15.48
Keywords
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Funding
- Swiss Federal Office of Public Health (BAG) [12.009410]
- Swiss National Science Foundation [PMPDP3_134081/1]
- Drug Prevention and Information Programme of the European Union [JUST/2011/DPIP/AG/3597]
- Swiss National Science Foundation (SNF) [PMPDP3_134081] Funding Source: Swiss National Science Foundation (SNF)
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Background: New psychoactive substances (NPS) have become increasingly prevalent and are sold in internet shops as bath salts' or research chemicals' and comprehensive bioanalytical methods are needed for their detection. Methodology: We developed and validated a method using LC and MS/MS to quantify 56 NPS in blood and urine, including amphetamine derivatives, 2C compounds, aminoindanes, cathinones, piperazines, tryptamines, dissociatives and others. Instrumentation included a Synergi Polar-RP column (Phenomenex) and a 3200 QTrap mass spectrometer (AB Sciex). Run time was 20 min. Conclusion: A novel method is presented for the unambiguous identification and quantification of 56 NPS in blood and urine samples in clinical and forensic cases, e.g., intoxications or driving under the influence of drugs.
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