Journal
POLYMER TESTING
Volume 31, Issue 8, Pages 1062-1069Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymertesting.2012.07.010
Keywords
Chitosan scaffolds; Electrospinning; Crystallinity; Biomaterials; Nanofibers
Funding
- FEDER funds through the Programa Operacional Factores de Competitividade - COMPETE
- FCT - Fundacao para a Ciencia e a Tecnologia [NANO/NMed-SD/0156/2007, SFRH/BPD/63148/2009, SFRH/BPD/64726/2009]
- COST Action [MP1003]
- Spanish Ministry of Science and Innovation [MAT2010-21611-C03-01]
- Programa Nacional de Internacionalizacion de la I+D project [EUI2008-00126]
- National NMR Network [REDE/1517/RMN/2005]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/64726/2009, NANO/NMed-SD/0156/2007] Funding Source: FCT
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Chitosan fiber mats were successfully processed by electrospinning. The as-spun fiber mats were neutralized with ethanol and cross-linked with glutaraldehyde. A decrease of the fiber average diameter from 243 +/- 43 nm down to 215.53 nm was observed for the neutralized and cross-linking chitosan membrane. It was found that the processing conditions do not alter the initial deacetylation degree of the polymer. Polymer crystallinity index showed a decrease from 61% for the Protasan material down to 17% for the cross-linking fiber mats. A swelling index up to 1000% was observed for the cross-linked samples. Preliminary MC-3T3-E1 cell culture results showed good cell adhesion and proliferation in the cross-linked chitosan fiber mats. (C) 2012 Elsevier Ltd. All rights reserved.
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