Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2015.00175
Keywords
CD44; adhesion molecule; hyaluronan receptor; extracellular matrix receptor
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Funding
- Foundation for Polish Science PARENT BRIDGE grant
- European Union Regional Development Fund
- National Science Centre [7873/B/P01/2011/40]
- European Regional Development Fund [POIG 01.01.02-00-008/08]
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CD44 is the major surface hyaluronan (HA) receptor implicated in intercellular and cellmatrix adhesion, cell migration and signaling. It is a transmembrane, highly glycosylated protein with several isoforms resulting from alternative gene splicing. The CD44 molecule consists of several domains serving different functions: the N -terminal extracellular domain, the stem region, the transmembrane domain and the C-terminal tail. In the nervous system, CD44 expression occurs in both glial and neuronal cells. The role of CD44 in the physiology and pathology of the nervous system is not entirely understood, however, there exists evidence suggesting it might be involved in the axon guidance, cytoplasmic Ca2-- clearance, dendritic arborization, synaptic transmission, epileptogenesis, oligodendrocyte and astrocyte differentiation, post traumatic brain repair and brain tumour development.
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