Journal
POLYMER JOURNAL
Volume 41, Issue 4, Pages 287-292Publisher
SPRINGERNATURE
DOI: 10.1295/polymj.PJ2008274
Keywords
MRI; Contrast Agent; Silsesquioxane; Dendrimer; Gadolinium; POSS
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Funding
- NEDO (New Energy and Industrial Technology Development Organization)
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We report that the cubic octameric polyhedral oligomeric silsesquioxanes (POSS)-core dendrimers, novel gadolinium (Gd) chelators, enhanced the proton relaxivity to Gd3+. The stability of the Gd complex with POSS(G1.5) was similar to those of DOTA and DTPA. From the MTT assay with the primary hepatocytes, the cytotoxicity of [Gd2POSS(G1.5)](2-) showed lower than that of the [Gd(DOTA)](-) complex. The detection limits were approximately 100-fold improved than those of DOTA and DTPA-Gd complexes in the MR images.
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