Journal
POLYMER INTERNATIONAL
Volume 63, Issue 12, Pages 2030-2041Publisher
WILEY
DOI: 10.1002/pi.4757
Keywords
polyhedral oligomeric silsesquioxane; 2-(dimethylamino)ethyl methacrylate; N-isopropylacrylamide; thermo- and pH-responsive; hydrogel
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Funding
- National Natural Science Foundation of China [20804041]
- Grants Program for Key Young Teachers in University of Henan Province
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Octavinyl polyhedral oligomeric silsesquioxane (OVPS) is used as the crosslinker instead of N,N-methylenebisacrylamide (BIS) to copolymerize with 2-(dimethylamino)ethyl methacrylate (DMAEMA) or DMAEMA and N-isopropylacrylamide (NIPAM) to prepare hybrid hydrogels: P(OVPS-co-DMAEMA) and P(OVPS-co-DMAEMA-co-NIPAM). The prepared hydrogels are transparent and show dual response to temperature and pH. The hydrogels were characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, dynamic mechanical analysis and tensile tests. Their mechanical properties, swelling ratio, deswelling and reswelling behaviors as well as drug release properties were investigated. The results indicate that OVPS can be incorporated into polymer networks in proportion to feed ratios. The P(OVPS-co-DMAEMA) hydrogel exhibits more homogeneous interior structure, higher swelling ratio and faster response than the conventional hydrogel prepared with BIS. Moreover, the incorporation of OVPS enhances the compression and tensile properties of the hydrogels. The feed ratios of OVPS and NIPAM have a great effect on volume phase transition temperature, thermal sensitivity, swelling behavior, mechanical properties and drug release properties of the hybrid hydrogels. The prepared dual-responsive OVPS-containing hydrogels are expected to be used as biomedical materials in drug release and tissue engineering. (c) 2014 Society of Chemical Industry
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