Journal
POLYMER DEGRADATION AND STABILITY
Volume 95, Issue 2, Pages 207-213Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymdegradstab.2009.11.023
Keywords
Porous scaffold; Polycaprolactone; Nano-hydroxyapatite; Degradation; Bone tissue engineering
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Funding
- Shanghai Municipal Science and Technology Commission [08ZR1412900]
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Porous nano-hydroxyapatite/polycaprolactone (nHA/PCL) scaffolds with different composition ratios of nHA/PCL were fabricated via a melt-molding/porogen leaching technique. All scaffolds were characterized before and after degradation in vitro for six months. The original scaffolds had high porosity at around 70% and showed decreasing compressive modulus (from 24.48 to 2.69 MPa for hydrated scaffolds) with the introduction of nHA. It was noted that the scaffolds could retain relatively stable architecture and mechanical properties for at least six months, although some slight changes happened with the nHA/PCL scaffolds in the mass, the nHA content, the PCL molecular weight and the crystallinity. Moreover, during the 7 days culture of bone marrow stromal cells (BMSCs) on scaffolds, the cell adhesion and proliferation of BMSCs were presented well on both the surface and the cross-section of the scaffolds. All of these results suggested the nHA/PCL scaffolds to be promising in bone tissue engineering. (C) 2009 Elsevier Ltd. All rights reserved.
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