Journal
POLYMER DEGRADATION AND STABILITY
Volume 95, Issue 4, Pages 694-701Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymdegradstab.2009.11.039
Keywords
Tissue engineering; Scaffold; Biodegradable polymer; In vitro degradation
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The aim of the study was to examine the relationship between the structural features of PLGA 3-D scaffolds and their degradation performances. PLGA 3-D scaffolds were fabricated by solvent casting and particulate leaching using salt and sucrose particles as porogen and they were characterized in terms of structure, physico-chemical and mechanical properties. The in vitro degradation study was performed at 37 degrees C in PBS for 28 days and it included the determination of Mw, Mn, PI, water uptake, mass loss and pH changes of the degradation buffer. It was found that the preparation method scaffolds, in particular the choice of the porogen type and was responsible for the three-dimensional structure (pore size, porosity, apparent density and, mechanical properties) of the scaffold and for physico-chemical PLGA polymer modifications (polymer degradation reactions, polymer chain rearrangement, Tg changes). Scaffolds with high porosity (83.8-89.4%) and an interconnected network were obtained. (C) 2009 Elsevier Ltd. All rights reserved.
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