Journal
POLYMER CHEMISTRY
Volume 5, Issue 5, Pages 1751-1759Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3py01204b
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Funding
- National Natural Science Foundation of China [21174076, 21104040, 51073090]
- National Basic Research Program of China [2009CB930602]
- Specialized Research Fund for the Doctoral Program of High Education of China [20120002110015]
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Voltage stimulus is considered as a clean and simple method in the field of stimuli-responsive polymer systems, in which the system based on beta-cyclodextrin (beta-CD) and ferrocene (Fc) has attracted considerable attention. Herein, we report voltage-responsive micelles based on the assembly of two biocompatible homopolymers, namely, the poly(ethylene glycol) homopolymer modified with beta-CD (PEG-beta-CD) and the poly(L-lactide) homopolymer modified with Fc (PLLA-Fc). Through host guest interactions between beta-CD and Fc, the two homopolymers connect together, forming a non-covalent supramolecular block copolymer PLLA Fc/PEG-beta-CD. PLLA Fc/PEG-beta-CD can further self-assemble to form stable micelles in aqueous solution. Through electrochemical control, a reversible assembly disassembly transition of this micellar system was realized. Voltage-controlled drug release based on this system was also conducted successfully.
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