4.7 Article

Formation-dissociation of glucose, pH and redox triply responsive micelles and controlled release of insulin

Journal

POLYMER CHEMISTRY
Volume 5, Issue 13, Pages 3968-3971

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4py00463a

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Funding

  1. National Basic Research Program of China (973 Program) [2011CB013805]
  2. National Key Technology RD Program [2012BAI15B061]
  3. National High Technology Research and Development Program [2013AA032202]

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An amphiphilic copolymer containing PEO and PAPBA linked by a disulfide bond (PEO-SS-PAPBA) was synthesized by RAFT. The micelles with a PEO shell and a PAPBA core presented glucose, pH and redox triple responses. The controlled release of insulin could be achieved through adding glucose or GSH.

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