Journal
POLYMER CHEMISTRY
Volume 5, Issue 23, Pages 6656-6661Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4py00995a
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Funding
- National Science Foundation of China [21104039]
- National 973 Project [2011CB935700]
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Theranostic combinations usually contain an imaging, a therapeutic and a cloaking component to simultaneously fulfil diagnostic and therapeutic functions. Using upgraded PEGylation technology, a straightforward one-pot strategy based on thiolactone ring-opening has been developed to facilely synthesize a multifunctional PEGylation agent, fluorescent protein-reactive poly(ethylene glycol) (PEG), which can subsequently react with a model therapeutic protein to form a fluorescent PEGylated protein as a model of sophisticated theranostic combinations.
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