Journal
POLYMER CHEMISTRY
Volume 5, Issue 13, Pages 4002-4008Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4py00030g
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Funding
- National Natural Science Foundation of China [21274121, 51173163]
- Major State Basic Research Project [2011CB606001]
- National Science-technology Support Plan Project of China [2012BAI07B01]
- Fundamental Research Funds for the Central Universities [2012QNA7043]
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In this work, fully biodegradable antimicrobial hydrogels were prepared facilely via a thiol-ene click reaction under human physiological conditions using multifunctional poly(ethylene glycol) (PEG) derivatives as precursors. Water soluble and degradable PEG derivatives with multi-enes and multi-thiols, respectively, were synthesized by polycondensation of oligo(ethylene glycol) (OEG) with clickable monomers. Ammonium groups with long alkyl chains were incorporated into one of the precursors covalently, using dodecyl bis(2-hydroxyethyl) methylammonium chloride as a comonomer. Proton nuclear magnetic resonance (H-1-NMR) spectroscopy, gel permeation chromatography (GPC) and Fourier transform infrared spectroscopy (FT-IR) were used to characterize the precursors and hydrogels. These types of cationic PEG-type hydrogels showed strong antibacterial abilities against both Gram-negative and Gram-positive bacteria due to the ammonium moieties. Moreover, the hydrogel with fewer ammonium moieties still possessed significant antibacterial abilities, but low toxicity, and has the potential to be used as a medical material.
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