Journal
POLYMER CHEMISTRY
Volume 5, Issue 16, Pages 4734-4746Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4py00495g
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Funding
- Natural Science Foundation Committee of China (NSFC) [61335007, 81371684, 81220108012, 81000666, 81171395, 81328012]
- Project Program of State Key Laboratory of Natural Medicines, China Pharmaceutical University [SKLNMZZYQ201403]
- Priority Academic Program Development of the Jiangsu Higher Education Institutions
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Conventional chemotherapy suffers from non-specificity, lack of aqueous solubility and multidrug resistance. Tumor-targeting nanotherapeutics exhibit unique advantages in the delivery of drugs specifically into tumors. Here, folic acid (FA), methionine (Met) and a near infrared (NIR) fluorescence probe (cypate, ICG derivative) were all bio-conjugated to succinyl-chitosan (SC) micelles. An anti-cancer drug (paclitaxel, PTX) was loaded into the hydrophobic cores of the formed FA-Met-SC-ICG derivative (FMSCI) micelles, which were under 200 nm in size. In comparison with micelles containing a single targeting moiety (FA or Met), FA and Met co-mediated micelles presented excellent biocompatibility, much higher affinity for cancer cells and excellent tumor-specific distribution in tumor-bearing mice. In vivo anti-tumor activity demonstrated that PTX-loaded FMSCI provided favourable therapeutic efficacy for tumors. In this research, novel nanotherapeutics based on FMSCI loaded with an anti-cancer drug provide a promising nanocomposite for combined tumor-targeting imaging and therapy.
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