Journal
POLYMER CHEMISTRY
Volume 4, Issue 19, Pages 5052-5055Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3py00849e
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Funding
- National Basic Research Program of China [2013CB932704, 2010CB934000, 2012CB932502]
- National Natural Science Foundation of China [81102388, 81270047]
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Wormlike micelles with intracellular pH-activating properties were developed. The micelles remained in a silent state at physiological pH conditions (i.e. pH 7.4), but were activated in the acidic microenvironment of endocytic vesicles. The wormlike micelles could be employed as nanovectors for the intracellular delivery of hydrophobic drugs for cancer therapy.
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