Journal
POLYMER CHEMISTRY
Volume 4, Issue 5, Pages 1694-1699Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2py21058d
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Funding
- Nation Science Foundation of China [20974103, 21074121, 21090354]
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A novel and versatile method for one-pot and in situ generation of bioreducible and acid labile nanogels/microgels simply via adding water into the polymerization system is reported. The produced polymers in the polymerization system become temperature-sensitive and less soluble after adding water, and hence they collapse together, forming nanoparticles. Subsequently, the disulfides inside the nanoparticle undergo intermolecular disulfide exchange to crosslink the nanoparticle into a bioreducible and acid labile nanogel/microgel. The size of the nanogel/microgel can be easily controlled by the polymerization time and the amount of water added. The formed nanogel/microgel is redox and pH responsive, and biocompatible.
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