Journal
POLYMER CHEMISTRY
Volume 3, Issue 11, Pages 3180-3188Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2py20380d
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Funding
- A*STAR
- Marie Curie Intraeuropean Fellowship
- Cambridge Overseas Trust
- ERC
- Walters-Kundert Foundation
- EPSRC [EP/F035535/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F035535/1] Funding Source: researchfish
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The synthesis of a supramolecular double hydrophilic glucose responsive block copolymer (DHBC) held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent self-assembly into micelles is described. The supramolecular block copolymer assembly consists of poly(N-isopropylacrylamide) (PNIPAAm) and poly(acrylamidophenyl boronic acid) (PAAPBA) as temperature and glucose responsive blocks, respectively, and poly(dimethylacrylamide) (PDMAAm) as a hydrophilic block. Drug release studies of insulin-loaded micelles using three external triggers were studied with release of insulin achieved by changing temperature, glucose concentration or by adding a competitive guest for CB[8]. This system offers good control over the release of insulin under physiological conditions (pH 7.4, 37 degrees C). These exciting results suggest that this system could be a model for a clinically relevant drug delivery vehicle for diabetic treatment.
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