Journal
POLYMER CHEMISTRY
Volume 2, Issue 6, Pages 1409-1414Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1py00016k
Keywords
-
Categories
Funding
- National Distinguished Young Investigator Fund [20725414]
- Science and Technology Cooperation Project of China [51011120051]
- Science and Technology Cooperation Project of Australia [51011120051]
- Ministry of Science and Technology of China [2007CB936401]
Ask authors/readers for more resources
We have synthesized polyurethane (PU)-g-poly(ethylene glycol) (PEG) copolymers for protein resistance. A macroiniferter consisting of polyurethane (PU) with tetraphenylethane groups is synthesized by the reaction of 1,1,2,2-tetraphenyl-1,2-ethanediol and isocyanate-terminated prepolymer with poly(tetramethylene glycol) (PTMG) segments. Such a macroiniferter initiates the polymerization of poly(ethylene glycol) methyl ether methacrylate to yield the target copolymer. Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance spectroscopy ((1)H NMR) and thermal analysis confirm the structure of the copolymer. Thermogravimetric analysis (TGA) also shows that the introduction of PEG side chains slightly decreases the thermal stability of the polymer. By use of quartz crystal microbalance with dissipation (QCM-D) and surface plasmon resonance (SPR), we have investigated the adsorption of fibrinogen, bovine serum albumin (BSA) and lysozyme on a PU-g-PEG surface in real time. It shows that the PU-g-PEG surface can resist protein adsorption depending on the PEG content.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available