4.7 Article

Tuning the lower critical solution temperature of thermoresponsive polymers by biospecific recognition

Journal

POLYMER CHEMISTRY
Volume 2, Issue 7, Pages 1486-1489

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1py00001b

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Funding

  1. The initiative Spitzenforschung & Innovation in den neuen Landern of the German Federal Ministry of Education and Research (BMBF) [03152201]

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A thermosensitive statistical copolymer based on oligo(ethylene glycol) methacrylates incorporating biotin was synthesized by free radical copolymerisation. The influence of added avidin on its thermoresponsive behaviour was investigated. The specific binding of avidin to the biotinylated copolymers provoked a marked increase of the lower critical solution temperature.

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