Journal
POLYMER CHEMISTRY
Volume 1, Issue 6, Pages 854-859Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0py00025f
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Funding
- National Science Foundation [DMR-0846792]
- Oak Ridge Associated Universities
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1265388] Funding Source: National Science Foundation
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Well-defined temperature-responsive polymers were covalently conjugated to model proteins by two consecutive Michael addition thiol-ene reactions. Poly(N-isopropylacrylamide) (PNIPAM) prepared by reversible addition fragmentation chain transfer (RAFT) polymerization was aminolyzed to yield thiol-terminated chains that were subsequently reacted with excess 1,8-bis-maleimidodiethyleneglycol. The resulting maleimide-terminated polymer was reacted with bovine serum albumin and ovalbumin to yield polymer protein conjugates by a grafting-to approach. The thermoresponsive nature of PNIPAM was conferred to the conjugate, as demonstrated by dynamic light scattering analysis that indicated the formation of intermolecular aggregates at elevated temperatures.
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