Journal
POLYMER BULLETIN
Volume 76, Issue 3, Pages 1423-1434Publisher
SPRINGER
DOI: 10.1007/s00289-018-2450-7
Keywords
Bioprosthetic heart valves; Calcification; Alginate; Dopamine; Ionic exchange
Categories
Funding
- National Natural Science Foundation of China [31700833]
- Young Elite Scientists Sponsorship Program by CAST [2017QNRC001]
- Fundamental Research Funds for the Central Universities [YJ201641]
- National Key Research and Development Programs [2017YFC1104200, 2016YFC1102200]
- Program of Introducing Talents of Discipline to Universities (111 Project) [B16033]
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Calcification is one of the main causes for bioprosthetic heart valves (BHVs)' failure. Reported strategies to improve BHVs' anti-calcification properties only target some of risk factors for calcification. In the current study, we demonstrated dopamine-modified alginate coating served as a protected layer for BHVs' anti-calcification. Alginate coating was characterized by infrared spectroscopic analysis, ultraviolet spectrophotometer, and water contact angle test. By both high-calcium and high-phosphorus in vitro calcification model and rat subdermal implant in vivo calcification model, our results showed alginate-coated BHVs' have greatly improved BHVs' anti-calcification performance due to constant ionic exchange of calcium and sodium. Besides, alginate-coated BHVs did not change BHVs' mechanical strength and tissue's shrink temperature. This was the first proof-of-concept study to verify that alginate coating would be a novel method for BHVs' anti-calcification.
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