Journal
POLYMER
Volume 55, Issue 2, Pages 540-549Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2013.12.037
Keywords
Glycopeptide; Vesicle; Encapsulant
Categories
Funding
- National Science Council [NSC102-2221-E-006-267]
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Amphiphilic glycopeptides, carboxylmethyl chitosan-graft-poly(gamma-benzyl-L-glutamate) (m-Chi-g-PBLG), were synthesized through ring-opening polymerization of gamma-benzyl-L-glutamate N-carboxyanhydride (NCA) using short chained m-Chi as the macroinitiator and employed to form vesicles in aqueous solution. The elemental and NMR analyses revealed that the polymerization degree (DP) of grafted PBLG could be tuned by varying the feed ratio of NCA to m-Chi. The conformation of the grafted PBLG chains transformed from beta-sheet to alpha-helix was correlated with the PBLG chain length. The m-Chi-g-PBLG vesicles can be prepared using double emulsion method and their sizes can be adjusted between 140 and 250 nm. The encapsulation of a model compound, FITC-dextran, in the vesicles revealed their potential applications as encapsulants or carriers. The in vitro release data revealed that a sustained release of FITC-dextran for a time period over two weeks can be achieved. (C) 2013 Elsevier Ltd. All rights reserved.
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