Journal
POLYMER
Volume 55, Issue 7, Pages 1756-1762Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2014.02.029
Keywords
The breath figure method; Photo-crosslinking; MC3T3-E1 cell behavior
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Funding
- University of Tennessee, National Science Foundation [DMR-11-06142]
- Center for Materials Processing in the department
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1106142] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1159344] Funding Source: National Science Foundation
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Honeycomb films of crosslinked poly(epsilon-caprolactone) triacrylate were fabricated by incorporating the breath-figure method with photo-curing. Two different pore sizes of 5.6 and 3.0 mu m were achieved by modulating the airflow rate at 0 and 50 mL min(-1), respectively. Mouse pre-osteoblastic MC3T3-E1 cell adhesion, spreading, proliferation, mineralization, and expression of integrin subunits of alpha(1), alpha(2), beta(1), and gene markers of osteocalcin, osteopontin, alkaline phosphatase (ALP), and collagen type I were investigated on these two series of honeycomb films and their flat control. The honeycomb films, especially those with smaller pores, could significantly promote MC3T3-E1 cell adhesion, spreading, proliferation, ALP activity, mineralization, and gene expression of osteoblastic markers, via fostering expression of integrin subunits. (C) 2014 Elsevier Ltd. All rights reserved.
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