Journal
POLYMER
Volume 53, Issue 15, Pages 3053-3078Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2012.04.047
Keywords
Polyethers; Non-ionic surfactants; Dendritic polymers; Drug delivery systems
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Funding
- Bundesministerium fur Bildung und Forschung (BMBF)
- Indo-German Science & Technology Centre (IGSTC)
- Departments of Science & Technology (DST), Delhi
- Deutscher Akademischer Austausch Dienst (DAAD) [SFB 765]
- University of Delhi
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The bioavailability of hydrophobic drugs is critically dependent on the development of efficient and safe drug delivery vehicles. Nanoparticulate pharmaceutical carriers commonly used in delivery of active components are often non-ionic in nature. Among them polyether based amphiphiles have become increasingly relevant over the past decades. Polyether based amphiphiles exhibit good chemical stability, high water solubility, low toxicity, have decreased interaction with blood components, and are highly biocompatible; and thus have been applied in biomedical and pharmaceutical areas. The current review highlights the synthetic progression and biomedical applications of these non-ionic polyether-based amphiphilic architectures, some unresolved issues and challenges, along with the future perspective of polyether based nanocarriers for delivery of active components. (C) 2012 Elsevier Ltd. All rights reserved.
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