Journal
POLYMER
Volume 51, Issue 19, Pages 4398-4407Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2010.07.025
Keywords
Supramolecular hydrogel; Cyclodextrin inclusion; Polysaccharide nanocrystal
Categories
Funding
- National Natural Science Foundation of China [20404014, 50873080, 50843031]
- Chinese Ministry of Science and Technology [2007CB936104, 2009CB930300]
- Energy Research and Development (PERD) of Canada
- Agricultural Bio-products Innovation Program (ABIP) of Canada via the Pulse Research Network (PURENET)
- Shanghai Municipality Commission [0952nm05300, 10410710000, 09540709000]
- Foundation for New Century Excellent Talents in University of Ministry of Education of China [NCET-10-0435]
- Youth Chenguang Program of Science & Technology in Wuhan [200850731383]
- State Key Laboratory of Pulp and Paper Engineering [200906]
- Fundamental Research Funds for the Central Universities [WUT 2010-II-022, JUSRT30905]
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Polysaccharide nanocrystals, such as the rod-like whiskers of cellulose and chitin, and platelet-like starch nanocrystals, were for the first time incorporated into supramolecular hydrogels based on cyclodextrin/polymer inclusion in order to enhance mechanical strength and regulate drug release behavior The structures and properties of the resultant nanocomposite hydrogels were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and rheological testing As expected, the elastic modulus of the nanocomposite hydrogels climbed, owing to the reinforcing function of the polysaccharide nanocrystals The modulus of the cellulose whisker-doped hydrogel was 50 times higher than that of the native hydrogel Furthermore, the presence of polysaccharide nanocrystals increased the stability of the hydrogel framework and inhibited the diffusion of bovine serum albumin, which served as a model protein drug in the nanocomposite hydrogels and showed prominent sustained release profiles Importantly, the incorporation of polysaccharide nanocrystals did not show additional cytotoxicity as comparison with the native hydrogel In addition, the inherited shear-thinning property of the nanocomposite hydrogels contributed to their potential as injectable biomaterials (C) 2010 Elsevier Ltd All rights reserved.
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