Journal
POLYMER
Volume 51, Issue 6, Pages 1311-1319Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2010.01.026
Keywords
Photo cross-linking; Nanogel; Micelle
Categories
Funding
- Natural Science Foundation of China (NSFC) [20774082, 50830106]
- Ministry of Education of China [20070335024]
- Science Foundation of Chinese University
- Open Project of State Key Laboratory of Supramolecular Structure and Materials [SKLSSM200911]
- Natural Science Foundation of China of Zhejiang Province [Y4080250]
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Poly(butanechoic acid, 1-[3-[(2-methyl-1-oxo-2-propen-1-yl)oxy]propy]) ester)-b-poly(methoxydi(ethylene glycol) methacrylate-co-4-methyl-[7-(methacryloyl)oxyethyloxy] coumarin) (PSPMA-b-P(DEGMMA-co-CMA)) block copolymer was synthesized via atom transfer radical polymerization (ATRP) The temperature and pH responsive micellization behaviors of PSPMA-b-P( DEGMMA-co-CMA) were investigated to obtain P(DEGMMA-co-CMA)-core and PSPMA-core micelles. After the two types of micelles were exposed to 365 nm UV light, core cross-linked (CCL) micelles and shell cross-linked (SCL) micelles were facilely prepared The photo cross-linking was proved to be reversibly controlled under alternative irradiation of 365 nm and 254 nm UV light More interestingly, block copolymer nanogels were fabricated by translating the hydrophobic core of the CCL and SCL micelles into hydrophilic via adjusting the temperature and pH. The sizes of the block copolymer nanogels can be facilely controlled by UV light irradiation The introduction of reversibly photo cross-linkable groups into the double responsive block copolymers provides a novel approach to develop more sophisticated, controllable, and smarter nanocarriers that might have great potentials in biomedical applications (C) 2010 Elsevier Ltd. All rights reserved
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