Journal
POLYMER
Volume 51, Issue 10, Pages 2161-2167Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2010.03.036
Keywords
Nanogel; Cationic; RAFT
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Funding
- National Natural Science Foundation of China [20874095]
- National Basic Research Program of China [2007CB210201, 2010CB923302]
- Fundamental Research Funds for the Central Universities
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Cationic nanogels of Pegylated poly(N,N'-Dimethylaminoethyl methacrylate) (PEG-PDAEMA) have been synthesized in aqueous solution by a one-step surfactant-free reversible addition-fragmentation transfer (RAFT) process. A Pegylated amphiphilic macroRAFT agent (mPEG(550)-TTC) with a hydrophobic dodecyl chain was utilized to stabilize the micelles and control the polymerization and crosslinking of DMAEMA in aqueous solution. (1)H NMR, GPC, Elemental analysis, Dynamic light scattering (DLS), Zeta potential and Atomic force microscopy (AFM) measurements confirmed the formation of the cationic nanogels in size of about 20 nm with a narrow distribution. It also revealed that the concentration of monomer and the kinds of crosslinker are the key factors to control the formation of nanogel. This cationic nanogel has potential application in gene delivery. (C) 2010 Elsevier Ltd. All rights reserved.
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