Journal
POLYMER
Volume 51, Issue 6, Pages 1336-1340Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2009.04.003
Keywords
Conjugated polymers; Synthesis; MRI contrast agent
Categories
Funding
- Chinese Academy of Sciences, the National Natural Science Foundation of China [20725308, 20601027, 20721061]
- National Basic Research Program of China [2006CB806200]
- Major Research Plan of China [2006CB932102]
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Nuclear magnetic resonance imaging (MRI) has become a powerful technique in clinical diagnostics. In this work, a new MRI contrast agent by covalently linking Gd(III) chelates to the side chain of conjugated polymer (PF-Gd) is synthesized by Suzuki cross-coupling reaction. The PF-Gd exhibits a higher relaxivity and a pronounced enhancement in contrast than that of (NMG)(2)-Gd-DTPA widely used for clinical diagnosis. This work should be feasible to potentially lead to a new class of imaging contrast agents (C) 2009 Elsevier Ltd. All rights reserved
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