Journal
POLYMER
Volume 51, Issue 18, Pages 4127-4139Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2010.06.060
Keywords
Biodegradable; Layer-by-layer composite films; Poly(D,L-lactic acid) particles
Categories
Funding
- National Science Foundation [NSF-CBET-NIRT 0650705]
- Air Force Office of Scientific Research [FA9550-08-1-0446]
- COLCIEN-CIAS
- Universidad de Antioquia, Colombia
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We designed and fabricated multilayer assemblies of biodegradable poly(lactic acid) (PLA) nanoparticles based on hydrogen-bonding or electrostatic interactions. The PLA nanoparticles were prepared by precipitation method and their surface charge was switched by modified precipitation in the presence of poly(ethylene imine) (PEI). Moreover, gold nanoparticles were grown within the PLA nanoparticle assemblies either through UV-irradiation or under mild reducing conditions to create biodegradable nanocomposites with distinct optical response which allows monitoring biodegradation of the films. The nanocomposite coatings of PLA nanoparticles were enzymatically degraded by alpha-chymotrypsin. We demonstrated that the biodegradation process can be colorimetrically monitored with UV-vis spectroscopy thus opening the way for facile and real-time monitoring useful for biotechnology applications. (C) 2010 Elsevier Ltd. All rights reserved.
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