Journal
POLYMER
Volume 51, Issue 5, Pages 1002-1009Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2010.01.001
Keywords
Chitosan; alpha-Cyano-4-hydroxycinnamic acid; Photo-crosslinkable
Categories
Funding
- Egyptian culture affairs and missions sectors
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In order to develop a non toxic and biocompatible hydrogel system with potential ability in biotechnology, modified photo-crosslinkable hydrogel membranes based on chitosan were prepared. Using an EDC/NHS conjugation method, chitosan was chemically modified to incorporate a photosensitive alpha-cyano-4-hydroxycinnamic acid moiety with various degrees of substitutions. Fourier transform infrared spectra (FTIR), proton nuclear magnetic resonance (H-1 NMR) and ultraviolet-visible light spectra (UV-vis) were used for structural characterization of modified chitosan, The obtained membranes were crosslinked by irradiation in the ultraviolet region, where the photosensitive monomers showed maximum sensitivity. The prepared photo-crosslinked hydrogel membranes were investigated by thermal gravimetric analysis (TGA) and wide angle X-ray diffraction (WAXD). The swelling behaviors were investigated in terms of pH, time of swelling, and degree of substitution. Also, mechanical properties of the different photo-crosslinked hydrogel membranes were studied in both dry and wet conditions. (C) 2010 Elsevier Ltd. All rights reserved.
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