Journal
POLYMER
Volume 50, Issue 15, Pages 3638-3644Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2009.05.024
Keywords
Biocompatible block copolymers; Nanogels; Drug delivery
Categories
Funding
- Ministry of Education of the Czech Republic [MSM0021620857]
- Grant Agency of the Czech Republic [203/07/0659]
- Grant Agency of the Academy of Sciences of the Czech Republic [IAA401110702]
- Academy of Sciences of the Czech Republic
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The self-assembly of two star copolymers, each consisting of four diblock arms of either poly(epsilon-caprolactone)-block-poly(ethylene oxide), PCL-PEO, or polylactide-block-poly(ethylene oxide), PLA-PEO, with PEO blocks in the centers of the stars, have been studied by a combination of light scattering, atomic force microscopy, fluorometry and (1)H NMR spectroscopy. Results of the study show that despite the very similar architecture of both star copolymers, the structures of their self-assembled nanoparticles differ. Unlike the (PLA-PEO)(4) star copolymer which forms core/shell flower-like micelles, the association of the (PCL-PEO)(4) copolymer leads to large micellar aggregates in which individual micelles are interconnected by shared unimers, having joint coronas formed by hydrophilic centers of the stars. (C) 2009 Elsevier Ltd. All rights reserved.
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