Journal
POLYMER
Volume 49, Issue 18, Pages 3950-3956Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2008.07.003
Keywords
water dispersible; magnetite; nanoparticle
Categories
Funding
- The Thailand Research Fund (TRF)
- Commission on Higher Education (CHE) [RMU4980006]
- Center for Innovation in Chemistry: Postgraduate Education and Research Program in Chemistry (PERCH)
Ask authors/readers for more resources
In this work, we report a synthetic method of water dispersible magnetite nanoparticles having oleic acid and poly(ethylene glycol) methyl ether-poly(epsilon-caprolactone) (mPEG-PCL) amphiphilic block copolymer as polymeric stabilizers. The particles were prepared by coprecipitation of Fe(II) and Fe(III) in NH4OH and had bilayer surface with hydrophobic inner layer and hydrophilic corona. mPEG-PCL copolymer was synthesized by a ring-opening polymerization of epsilon-caprolactone using mPEG as a macroinitiator in the presence of stannous octoate catalyst. FTIR and thermogravimetric analysis (TGA) indicated the presence of the copolymer on the particle surface. Roles of reaction parameters, such as stabilizer concentrations and time of ultrasonicating treatment, on percent of magnetite in the complex and its magnetic properties were investigated. Transmission electron microscopy (TEM) showed the average particle size about 9.0 +/- 1.1 nm in diameter. Vibrating sample magnetometry (VSM) measurement indicated that the magnetite nanoparticles were superparamagnetic at room temperature. Approximately 6.8 +/- 0.5% of indomethacin model drug (68 mu g/mg of magnetite) was effectively entrapped on the particles. (C) 2008 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available