Journal
POLYMER
Volume 49, Issue 22, Pages 4784-4790Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2008.08.052
Keywords
Polyphosphoester; Drug delivery; Biodegradable polymer
Categories
Funding
- National Natural Science Foundation of China [50733003, 20774089]
- Ministry of Sciences and Technology of the People's Republic of China [2006CB933300, 2009CB930300]
- Bairen Program of Chinese Academy of Sciences
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A series of novel 4-arm biodegradable star block copolymers of poly(epsilon-caprolactone) and poly(ethyl ethylene phosphate) were synthesized via ring-opening polymerization of 2-ethoxy-2-oxo-1,3,2-dioxa-phospholane using hydroxyl terminated 4-arm star-shaped poly(F-caprolactone) and stannous octoate co-initiation system. Gel permeation chromatography (GPC), NMR and FT-IR were used to demonstrate the structure and analyze their compositions. The self-assembly behavior of these star-shaped copolymers in aqueous solution was studied by H-1 NMR and fluorescence technique, and the results indicated those copolymers formed nanoparticles in aqueous solution with hydrophobic poly(E-caprolactone) core and hydrophilic poly(ethyl ethylene phosphate) shell. The critical micelle concentration was relative to the length of poly(epsilon-caprolactone) and poly(ethyl ethylene phosphate) block. Paclitaxel was encapsulated in the micelles and the release behavior demonstrated that a longer hydrophobic block resulted in slightly slower release rate from the micelles. These copolymer micelles were biocompatible and potential as drug-delivery vehicles for pharmaceutical application. (C) 2008 Elsevier Ltd. All rights reserved.
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