Journal
POLYHEDRON
Volume 30, Issue 15, Pages 2627-2636Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2011.07.014
Keywords
Thiazine; Pyrazole; Zinc(II) complexes; Crystal structures; Phagocytosis; Human neutrophils
Categories
Funding
- Junta de Extremadura (III PRI + D + I)
- FEDER [PRI08A022]
- MEC [AP2009-0753]
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The new ligands 2-(1-pyrazolil)-1,3-thiazine (PzTz), 2-(3,5-dimethyl-1-pyrazolil)-1,3-thiazine (DMPzTz) and 2-(3,5-diphenyl-1-pyrazolil)-1,3-thiazine (DPhPzTz) and the complexes [ZnCl2(H2O)(PzTz)] (1), [ZnCl2(DMPzTz)] (2) and [ZnCl2(DPhPzTz)] (3) have been isolated and then characterized by elemental analysis, IR spectra and UV-Vis spectroscopy. Besides, the crystal structure of ligands PzTz and DPhPzTz and complexes 1-3 have been determined by single-crystal X-ray diffraction. In 1, the geometry around the Zn(II) atom can be considered a highly distorted trigonal bipyramid, with the metallic atom bonded to two chlorine atoms, one water molecule and one bidentate PzTz ligand. In 2 and 3, the environment around the metal ion can be described as a distorted tetrahedron with the zinc atom coordinated to one bidentate organic ligand molecule and two chloro ligands. In addition, the phagocytic function of human neutrophils treated with complexes 1-3, their organic ligands and ZnCl2 has been evaluated. The activity of cells enhanced in samples treated with 1, 2 and 3 with respect to the ones to which the inorganic salt, PzTz. DMPzTz or DPhPzTz were added. (C) 2011 Elsevier Ltd. All rights reserved.
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